By in situ hybridization, Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21.
Genomics 18: 319-321, 1993.[Pub Med: 8288234] [Full Text]" pmid="8288234"Ouafik et al. They noted that the NEC1 gene (162150), which encodes another enzyme important in posttranslational processing of neuroendocrine precursors, prohormone convertase 1 (PC1), is located in the same region (5q15-q21).
This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.
Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’. This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.
Peptidylglycine alpha-amidating monooxygenase (EC 184.108.40.206) is a multifunctional protein containing 2 enzymes, peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL), that act sequentially to catalyze the alpha-amidation of neuroendocrine peptides. Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21.